About TCellXTalk

TCellXTalk is a database of protein post-translational modifications in human T cells built to facilitate the experimental detection of co-modified peptides using targeted or directed mass spectrometry. Currently, the database contains ~90,000 modified (phosphorylation, ubiquitination or acetylation) sites.

The data in TCellXTalk has been obtained from the literature or has been generated at the CSIC/UAB Proteomics Laboratory, part of the Spanish National Research Council (Consejo Superior de Investigaciones Científicas - CSIC).

References

Casanovas, A., Gallardo, Ó., Carrascal, M., Abian, J., TCellXTalk facilitates the detection of co-modified peptides for the study of protein post-translational modification cross-talk in T cells. Bioinformatics 2018, 2018. DOI: 10.1093/bioinformatics/bty805

Credits

This work has been carried out at CSIC/UAB Proteomics Laboratory, part of the Spanish National Research Council (Consejo Superior de Investigaciones Científicas - CSIC).

The people who has created and tested the database are:

  • Mass Spectrometry, study design and implementation: Montserrat Carrascal and Albert Casanovas
  • Sample preparation: Montserrat Carrascal and Albert Casanovas
  • Data analysis, bioinformatics and informatics: Óscar Gallardo
  • Direction: Joaquin Abian

Contact details can be found at the Contact section.

Funding

This work has been supported by the Spanish Ministry of Economy and Competitiveness (Grant BIO2013-46492-R).

The Proteomics Laboratory CSIC/UAB is a member of ProteoRed, PRB2-ISCIII and PRB3-ISCIII, and is supported by Grants PT13/0001/0008 and PT17/0019/0008, funded by ISCIII and FEDER.