TCellXTalk is a database of protein post-translational modifications in human T cells built to facilitate the experimental detection of co-modified peptides using targeted or directed mass spectrometry. Currently, the database contains ~90,000 modified (phosphorylation, ubiquitination or acetylation) sites.
The data in TCellXTalk has been obtained from the literature or has been generated at the CSIC/UAB Proteomics Laboratory, part of the Spanish National Research Council (Consejo Superior de Investigaciones Científicas - CSIC).
Casanovas, A., Gallardo, Ó., Carrascal, M., Abian, J., TCellXTalk facilitates the detection of co-modified peptides for the study of protein post-translational modification cross-talk in T cells. Bioinformatics 2018, 2018. DOI: 10.1093/bioinformatics/bty805
This work has been carried out at CSIC/UAB Proteomics Laboratory, part of the Spanish National Research Council (Consejo Superior de Investigaciones Científicas - CSIC).
The people who has created and tested the database are:
- Mass Spectrometry, study design and implementation: Montserrat Carrascal and Albert Casanovas
- Sample preparation: Montserrat Carrascal and Albert Casanovas
- Data analysis, bioinformatics and informatics: Óscar Gallardo
- Direction: Joaquin Abian
Contact details can be found at the Contact section.
This work has been supported by the Spanish Ministry of Economy and Competitiveness (Grant BIO2013-46492-R).